Long-range single-molecule mapping of chromatin modification in eukaryotes
Zhe Weng, Fengying Ruan, Weitian Chen, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Juan Wang, Yuxin Sun, Yitong Fang, Mei Li Guo, Yiqin Tong, Yaning Li, Chong Tang
The paper introduces a method called BIND&MODIFY to map histone modifications at the single-molecule level using long-read sequencing, revealing long-range chromatin states and heterogeneity.
bioRxiv · Jul 8, 2021 · PreprintGenomics