Zhichao Chen

Exploring DNA movement through the application of droplet based high efficient chromatin conformation capture (DropHiChew) and loop velocity

This paper introduces DropHiChew and loop velocity to study DNA movement dynamics, enabling accurate trajectory estimation with shallow sequencing.

High efficient chromatin conformation capture without pre-enrichment (HiChew) in single cells

HiChew improves chromatin conformation capture in single cells with higher efficiency, fewer false positives, and more contacts per cell compared to Dip-C.

Spatial chromatin accessibility sequencing resolves high-order spatial interactions of epigenomic markers

This study introduces SCA-seq to resolve spatial chromatin interactions at single-molecular resolution and demonstrates its application in analyzing epigenomic markers.

High coverage of single cell genomes by T7-assisted enzymatic methyl-sequencing

This study introduces TEAM-seq, a method for high-coverage 5mC sequencing in single cells, achieving 70% coverage at 100pg input DNA.

Long-range single-molecule mapping of chromatin modification in eukaryotes

The paper introduces a method called BIND&MODIFY to map histone modifications at the single-molecule level using long-read sequencing, revealing long-range chromatin states and heterogeneity.

Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure.

The paper introduces CCDA-seq to study ecDNA chromatin structure, revealing distinct nucleosome and regulator binding patterns.