Author

Fengying Ruan

BGI Group (China)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 5 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Assay:Hi-C· 2 Assay:bulk RNA-seq· 1 Assay:CUT&Tag· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Chong TangiD· 6 shared Mei Li GuoiD· 6 shared Yeming XieiD· 5 shared Yitong FangiD· 5 shared Zhichao CheniD· 5 shared Chen ZhangiD· 4 shared Weitian CheniD· 4 shared Yaning LiiD· 4 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersGenomics

Chong TangORCID

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6 papers

Recent·Most cited

High efficient chromatin conformation capture without pre-enrichment (HiChew) in single cells

Zhichao Chen, Yeming Xie, Chen Tan, Fengying Ruan, Meng Luo, Chen Zhang, Mei Li Guo, Yitong Fang, Chong Tang

HiChew improves chromatin conformation capture in single cells with higher efficiency, fewer false positives, and more contacts per cell compared to Dip-C.

bioRxiv · Jun 25, 2024 · PreprintGenomics

Spatial chromatin accessibility sequencing resolves high-order spatial interactions of epigenomic markers

Yeming Xie, Fengying Ruan, Yaning Li, Meng Luo, Chen Zhang, Zhichao Chen, Zhe Xie, Zhe Weng, Weitian Chen, Wenfang Chen, Yitong Fang, Yuxin Sun, Mei Li Guo, Juan Wang, Shouping Xu, , Chong Tang

This study introduces SCA-seq to resolve spatial chromatin interactions at single-molecular resolution and demonstrates its application in analyzing epigenomic markers.

eLife · Jan 18, 2024Peer-reviewedGenomics

High coverage of single cell genomes by T7-assisted enzymatic methyl-sequencing

Juan Wang, Yitong Fang, Wenfang Chen, Chen Zhang, Zhichao Chen, Zhe Xie, Zhe Weng, Weitian Chen, Fengying Ruan, Yeming Xie, Yuxin Sun, Mei Li Guo, Yaning Li, Chong Tang

This study introduces TEAM-seq, a method for high-coverage 5mC sequencing in single cells, achieving 70% coverage at 100pg input DNA.

bioRxiv · Feb 23, 2022 · PreprintGenomics

Long-range single-molecule mapping of chromatin modification in eukaryotes

Zhe Weng, Fengying Ruan, Weitian Chen, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Juan Wang, Yuxin Sun, Yitong Fang, Mei Li Guo, Yiqin Tong, Yaning Li, Chong Tang

The paper introduces a method called BIND&MODIFY to map histone modifications at the single-molecule level using long-read sequencing, revealing long-range chromatin states and heterogeneity.

bioRxiv · Jul 8, 2021 · PreprintGenomics

Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure.

Weitian Chen, Zhe Weng, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Fengying Ruan, Juan Wang, Yuxin Sun, Yitong Fang, Mei Li Guo, Yiqin Tong, Yaning Li, Chong Tang

The paper introduces CCDA-seq to study ecDNA chromatin structure, revealing distinct nucleosome and regulator binding patterns.

bioRxiv · Mar 31, 2021 · PreprintGenomics

miRNA-dependent poly(A) length control in uncoupling transcription and translation of haploid male germ cells

Chong Tang, Mei Li Guo, Zhuoxing Shi, Zhuqing Wang, Chunhai Luo, Sheng Chen, Fengying Ruan, Zhichao Chen, Linfeng Yang, Xiongyi Wei, Chuanwen Wu, Bei Luo, Zhou Lv, Jin Yuan Huang, Dong Zhang, , Fei Sun

The paper identifies miRNA-dependent poly(A) length regulation as a mechanism for uncoupling transcription and translation in spermatids.

bioRxiv · Mar 1, 2021 · PreprintMolecular Biology