Author
BGI Group (China)ORCID 0000-0002-1490-9237Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Chen Zhang, Yeming Xie, Chen Tan, Zhichao Chen, 慧敏 曹, Mei Guo, Luyang Zhao, Zhe Weng, Chong Tang
This paper introduces DropHiChew and loop velocity to study DNA movement dynamics, enabling accurate trajectory estimation with shallow sequencing.
Nucleic Acids Research · Oct 24, 2026Peer-reviewedGenomics
Yeming Xie, Fengying Ruan, Yaning Li, Meng Luo, Chen Zhang, Zhichao Chen, Zhe Xie, Zhe Weng, Weitian Chen, Wenfang Chen, Yitong Fang, Yuxin Sun, Mei Li Guo, Juan Wang, Shouping Xu, , Chong Tang
This study introduces SCA-seq to resolve spatial chromatin interactions at single-molecular resolution and demonstrates its application in analyzing epigenomic markers.
eLife · Jan 18, 2024Peer-reviewedGenomics
Juan Wang, Yitong Fang, Wenfang Chen, Chen Zhang, Zhichao Chen, Zhe Xie, Zhe Weng, Weitian Chen, Fengying Ruan, Yeming Xie, Yuxin Sun, Mei Li Guo, Yaning Li, Chong Tang
This study introduces TEAM-seq, a method for high-coverage 5mC sequencing in single cells, achieving 70% coverage at 100pg input DNA.
bioRxiv · Feb 23, 2022 · PreprintGenomics
Zhe Weng, Fengying Ruan, Weitian Chen, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Juan Wang, Yuxin Sun, Yitong Fang, Mei Li Guo, Yiqin Tong, Yaning Li, Chong Tang
The paper introduces a method called BIND&MODIFY to map histone modifications at the single-molecule level using long-read sequencing, revealing long-range chromatin states and heterogeneity.
bioRxiv · Jul 8, 2021 · PreprintGenomics
Weitian Chen, Zhe Weng, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Fengying Ruan, Juan Wang, Yuxin Sun, Yitong Fang, Mei Li Guo, Yiqin Tong, Yaning Li, Chong Tang
The paper introduces CCDA-seq to study ecDNA chromatin structure, revealing distinct nucleosome and regulator binding patterns.
bioRxiv · Mar 31, 2021 · PreprintGenomics