Mei Li Guo

HiChew improves chromatin conformation capture in single cells with higher efficiency, fewer false positives, and more contacts per cell compared to Dip-C.

This study introduces SCA-seq to resolve spatial chromatin interactions at single-molecular resolution and demonstrates its application in analyzing epigenomic markers.

The paper improves RNA velocity analysis by incorporating long-read single-cell sequencing to better capture gene expression dynamics and cell fate transitions.

This study introduces TEAM-seq, a method for high-coverage 5mC sequencing in single cells, achieving 70% coverage at 100pg input DNA.

The paper introduces a method called BIND&MODIFY to map histone modifications at the single-molecule level using long-read sequencing, revealing long-range chromatin states and heterogeneity.

The paper introduces CCDA-seq to study ecDNA chromatin structure, revealing distinct nucleosome and regulator binding patterns.

AASRA is a small RNA annotation pipeline that improves accuracy and speed by handling sncRNA variants and distinguishing mature from precursor miRNAs.

The paper identifies miRNA-dependent poly(A) length regulation as a mechanism for uncoupling transcription and translation in spermatids.

This study compares small RNA sequencing data from two exosome isolation kits, finding that ExoQuick provides better data quality and RNA profile than exoRNeasy.