Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding
Jingkun Zeng, Zhiyuan Cheng, Huadong Chen, Zhaojun Wang, Jared Thompson, Kadin T. Crosby, Hesong Han, Arushi Singhal, Wayne Ngo, Chenglong Xia, Daniel Rosas-Rivera, Zeyuan Terry Zhang, Min Hyung Kang, Ying Mao, Morgan E. Diolaiti, , Jennifer A. Doudna
This paper develops a method to selectively kill cancer cells with TP53 mutations by using RNA-guided Cas12a2 to induce chromatin shredding through targeting cancer-specific transcripts.
Nature · Jun 8, 2026Peer-reviewedCell Biology