Poly-alanine-tailing is a modifier of neurodegeneration caused by Listerin mutation
Hao‐Chih Hung, Carlos Costas‐Insua, Sarah E. Holbrook, Jennifer E. Stauffer, Paige B Martin, Tina Müller, David G. Schroeder, Yu Kigoshi-Tansho, Haifei Xu, Rüdiger Rudolf, Gregory A. Cox, Claudio A.P. Joazeiro
This study shows that impairing NEMF's poly-alanine-tailing activity in mice interacts with Listerin mutations to cause neurodegeneration, revealing a role for Ala-tailing in proteostasis and neurodegeneration.
bioRxiv · Aug 24, 2024 · PreprintBiochemistry