Sarah E. Holbrook

SORT LNPs enable efficient Cas9-mediated repair of a pathogenic allele in skeletal muscle in a mouse model of LGMDR7.

This study shows that impairing NEMF's poly-alanine-tailing activity in mice interacts with Listerin mutations to cause neurodegeneration, revealing a role for Ala-tailing in proteostasis and neurodegeneration.

The paper investigates the role of GLH-1/Vasa helicase domains in C. elegans germ granules, showing their necessity for granule association and their interaction with Argonaute proteins and PCI scaffolding complexes.