Carlos Costas‐Insua

Poly-alanine-tailing is a modifier of neurodegeneration caused by Listerin mutation

This study shows that impairing NEMF's poly-alanine-tailing activity in mice interacts with Listerin mutations to cause neurodegeneration, revealing a role for Ala-tailing in proteostasis and neurodegeneration.

The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls

This study identifies CB1R overactivation as a driver of CRBN deficiency-linked ARNSID and suggests CB1R blockade as a potential therapy.

Mechanism and evolutionary origins of Alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10

The paper investigates how Pirh2 and CRL2-KLHDC10 E3 ligases recognize Ala-tails, showing conserved binding sites and convergent evolution of their recognition mechanisms.