Yuichiro Ioi

Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors

This study shows that GPCRs regulate mTORC1 substrates differently, with M5R promoting protein synthesis while allowing lysosome biogenesis.

Calmodulin enhances mTORC1 signaling by preventing TSC2-Rheb binding

This study shows that calmodulin enhances mTORC1 signaling by blocking TSC2-Rheb binding in a Ca2+-dependent manner.