Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors
Samuel J. Atkinson, Florentina Negoita, Yuichiro Ioi, William V. Ritchie, Kyle Thompson, Max Gardner, Peter T. Ashdown, Kristina Hellberg, Terunao Takahara, Kei Sakamoto, Dawn Thompson, James N. Hislop, Riko Hatakeyama
This study shows that GPCRs regulate mTORC1 substrates differently, with M5R promoting protein synthesis while allowing lysosome biogenesis.
Biochemical Journal · Aug 20, 2026Peer-reviewedCell Biology