Author

Florentina Negoita

University of CopenhagenORCID 0000-0001-6032-0127Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

Kei SakamotoiD· 2 shared Kristina Hellberg· 2 shared Conchita Fraguas BringasiD· 1 shared Dawn ThompsoniD· 1 shared Gajanan J. SatheiD· 1 shared Gopal P. SapkotaiD· 1 shared Hongling LiuiD· 1 shared James N. HislopiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Kei SakamotoORCID

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2 papers

Recent·Most cited

Cell BiologyBiochemical JournalPeer-reviewedAug 20, 2026

Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors

Samuel J. Atkinson, Florentina Negoita, Yuichiro Ioi…·Riko Hatakeyama

This study shows that GPCRs regulate mTORC1 substrates differently, with M5R promoting protein synthesis while allowing lysosome biogenesis.

DOI 10.1042/bcj20260165

proteomicsexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintOct 22, 2024

AMPK activation promotes transcriptional activation of TFEB through its dephosphorylation

Florentina Negoita, Conchita Fraguas Bringas, Kristina Hellberg…·Kei Sakamoto

The paper shows that AMPK activation leads to dephosphorylation of TFEB's C-terminal sites, promoting its transcriptional activation, and that AMPK is not required for mTORC1-mediated TFEB activation.

DOI 10.1101/2024.10.22.619589

proteomicsexperimental assay

𝕏 PostBluesky