Tissue Injury and Biomaterial Treatment Modulate Tumor Growth and Response to Immunotherapy
Anna Ruta, Elise F. Gray-Gaillard, Jordan A. Garcia, Locke Davenport Huyer, Yusef Mathkour, Christopher Cherry, Michael Patatanian, Joscelyn C. Mejías, David R. Maestas, Kavita Krishnan, Peter Abraham, Matthew T. Wolf, Kellie Nicole Smith, Drew M. Pardoll, Jennifer H. Elisseeff
This study shows that tissue injury accelerates tumor growth and reduces response to immunotherapy in mice, but biomaterials that enhance wound healing can improve outcomes and ICB response.
bioRxiv · Feb 4, 2026 · PreprintCancer Biology