Elise F. Gray-Gaillard

γδ17 T cell-stromal networks modulate matrix composition and vascularity in foreign body response

This study shows that γδ17 T cells influence fibrosis by altering ECM composition and vascularity through interactions with stromal cells.

3D, multi-omic imaging reveals molecular biomarkers of the pre-metastatic niche in lung cancer

This study uses 3D multi-omic imaging to identify biomarkers of the pre-metastatic niche in lung cancer, revealing myeloid and senescent cell signatures associated with metastasis risk.

Tissue Injury and Biomaterial Treatment Modulate Tumor Growth and Response to Immunotherapy

This study shows that tissue injury accelerates tumor growth and reduces response to immunotherapy in mice, but biomaterials that enhance wound healing can improve outcomes and ICB response.

Immune checkpoint inhibitors amplify type 2 immune mediated repair bypro-regenerative scaffolds

This study shows immune checkpoint inhibitors enhance type 2 immunity and regeneration in ECM-treated wounds by promoting Treg/TH2 plasticity and pro-regenerative macrophages.

Regulatory T cells clonally expand and contribute to stromal cell function in fibrotic response to synthetic implants

The paper identifies Treg clonal expansion and immunosuppressive functions in fibrosis induced by synthetic implants, showing their role in modulating stromal cell behavior.

Antibiotic-induced microbiota depletion impairs the pro-regenerative response to a biological scaffold in mice

This study shows antibiotic-induced microbiota depletion in mice impairs the pro-regenerative immune response to a biological scaffold, reducing myocyte regeneration and increasing fibrosis.

Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant

This study shows that gut microbiota dysbiosis from enteric infection increases immune cell recruitment to a distant biomaterial implant, affecting the foreign body response.

Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback

The paper models the complete kinetics of coxsackievirus B3 to identify human determinants of host-cell feedback, revealing that MAVS cleavability influences viral outcomes.