Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling
Jian Tang, Xian Jia, Taoling Zeng, Yuzhou Bao, Yanyan Hu, Junchen Dong, Xiaozheng Xu, Xiao Lei Chen, Yongchao Liu, Jiayu Wang, Bowen Hou, Yuzhen Zhu, Guofeng Fu, Qi‐Fan Zheng, Yongling Chen, , Guo Fu
This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.
bioRxiv · Feb 17, 2025 · PreprintImmunology