Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein
M. P. Doyle, N. Kose, V. Borisevich, E. Binshtein, M. Amaya, M. Nagel, E. J. Annand, E. Armstrong, R. Bombardi, J. Dong, K. L. Schey, C. C. Broder, L. Zeitlin, E. Kuang, Z. Bornholdt, , J. E. Crowe
This study identifies human monoclonal antibodies that neutralize HeV and NiV by targeting distinct antigenic sites on the receptor binding protein and demonstrates their cooperative binding and synergistic therapeutic effects.
bioRxiv · Feb 17, 2021Immunology