L. Zeitlin

Crimean-Congo Hemorrhagic Fever Survivors Elicit Protective Non-Neutralizing Antibodies that Target 11 Overlapping Regions on Viral Glycoprotein GP38

The paper identifies non-neutralizing antibodies from CCHFV survivors that target multiple regions on GP38, showing protective efficacy in rodent models.

Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a pan-Ebolavirus Immunotherapeutic

This study shows that a single intramuscular dose of MBP431, a modified ebolavirus therapeutic, can reverse disease and provide protection in non-human primates.

Hexavalent Sperm-Binding IgG Antibody Released from Self-Dissolving Vaginal Film Enables Potent, On-Demand Non-Hormonal Female Contraception

This paper develops a non-hormonal contraceptive method using a hexavalent sperm-binding antibody delivered via a dissolving vaginal film, showing potent sperm inhibition in sheep.

Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

This study identifies human monoclonal antibodies that neutralize HeV and NiV by targeting distinct antigenic sites on the receptor binding protein and demonstrates their cooperative binding and synergistic therapeutic effects.

Inhibition of Invasive Salmonella by Orally Administered IgA and IgG Monoclonal Antibodies

This study shows orally administered IgA and SIgA monoclonal antibodies can reduce Salmonella Typhimurium uptake in Peyers patches, while IgG is less effective, highlighting the need for improved formulations to sustain mAb activity in the gut.

Therapeutic Treatment of Aerosolized Staphylococcal Enterotoxin B in Nonhuman Primates with two Monoclonal Antibodies

Two monoclonal antibodies were tested for therapeutic efficacy against aerosolized SEB in a nonhuman primate model, showing survival in treated animals compared to untreated controls.

Human antibody cocktail deploys multiple functions to confer pan-ebolavirus protection

This paper develops a human antibody cocktail, MBP134, that provides broad protection against multiple ebolaviruses, showing enhanced efficacy in guinea pigs compared to individual antibodies.

Two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates

This paper demonstrates that a two-antibody cocktail (MBP134AF) provides broad therapeutic protection against multiple ebolaviruses in ferrets and nonhuman primates.