Author

E. Kuang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

X. Li· 3 shared X. ZhangiD· 3 shared Z. Yang· 3 shared F. Wang· 2 shared L. Zeitlin· 2 shared R. W. Cross· 2 shared V. Borisevich· 2 shared A. Marimuthu· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

X. Li

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a pan-Ebolavirus Immunotherapeutic

E. Kuang, R. W. Cross, M. McCavitt-Malvido, D. M. Abelson, V. Borisevich, K. N. Agans, N. Mlakar, A. Marimuthu, D. J. Deer, W. S. Shestowsky, D. Kim, J. B. Geisbert, L. Zeitlin, C. L. Moyer, C. J. Roy, , Z. A. Bornholdt

This study shows that a single intramuscular dose of MBP431, a modified ebolavirus therapeutic, can reverse disease and provide protection in non-human primates.

bioRxiv · Jan 6, 2022Microbiology

RTN3 inhibits RIGI-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination

Z. Yang, J. Wang, B. He, X. Zhang, X. Li, E. Kuang

This study identifies RTN3 as a proresolving mediator that suppresses antiviral responses by inhibiting TRIM25-mediated K63-linked polyubiquitination of RIG-I, reducing neutrophil infiltration and inflammation.

eLife · Jul 27, 2021Peer-reviewedImmunology

Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

M. P. Doyle, N. Kose, V. Borisevich, E. Binshtein, M. Amaya, M. Nagel, E. J. Annand, E. Armstrong, R. Bombardi, J. Dong, K. L. Schey, C. C. Broder, L. Zeitlin, E. Kuang, Z. Bornholdt, , J. E. Crowe

This study identifies human monoclonal antibodies that neutralize HeV and NiV by targeting distinct antigenic sites on the receptor binding protein and demonstrates their cooperative binding and synergistic therapeutic effects.

bioRxiv · Feb 17, 2021Immunology

Sequential ER stress and inflammatory responses are induced by SARS-CoV-2 ORF3 through ERphagy

X. Zhang, Z. Yang, X. Long, Q. Sun, F. Wang, P.-h. Wang, X. Li, E. Kuang

This study identifies SARS-CoV-2 ORF3 as an inducer of ERphagy, leading to ER stress and inflammatory responses, which may be targeted for COVID-19 treatment.

bioRxiv · Nov 17, 2020 · PreprintMicrobiology

Suppression of MDA5-mediated antiviral immune responses by NSP8 of SARS-CoV-2

Z. Yang, X. Zhang, F. Wang, P. Wang, X. Li, E. Kuang

This study identifies NSP8 as a SARS-CoV-2 protein that suppresses MDA5-mediated antiviral immune responses by inhibiting type I IFN signaling.

bioRxiv · Aug 12, 2020 · PreprintMicrobiology