Z. Borok

Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma

This study shows that the cell of origin in lung adenocarcinoma affects the immunosuppressive state of the tumor microenvironment, with AT1-derived tumors showing an anti-tumor immune profile and AT2-derived tumors showing immunosuppressive features.

GRAMD2+ alveolar type I cell plasticity facilitates cell state transitions in organoid culture

The paper identifies GRAMD2+ alveolar type I cells as plastic and capable of transitioning through multiple lung epithelial cell states in organoid culture.

RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis

The paper identifies RBL2 as a repressor of Multicilin's transcriptional activity, showing it inhibits multiciliogenesis in airway epithelial cells.

Context-dependent functions of mitochondria protein quality control in lung

This study shows that mitochondrial protein quality control via LONP1 is context-dependent in lung epithelial cells, affecting proliferation, differentiation, and migration through the integrated stress response.

Targeting caveolae to pump bispecific antibody to TGF-β into diseased lungs enables ultra-low dose therapeutic efficacy

This paper develops a bispecific antibody that targets caveolae to deliver TGF-β inhibitors specifically to lungs, achieving ultra-low dose therapeutic efficacy in a rat model.

Development of novel in vitro human alveolar epithelial cell models to study distal lung biology and disease

The paper develops novel immortalized human alveolar epithelial cell lines that can form organoids and exhibit lineage memory, offering a new in vitro model for distal lung biology and disease.

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

Single Cell Transcriptomics-guided Antisense Treatment Improves Endoderm Differentiation of iPSCs

The paper develops a method to enhance endoderm differentiation of iPSCs by suppressing transcription factors identified through single-cell RNA sequencing, increasing endodermal cell yield by up to 20-fold.