C. M. Hogaboam

Caveolin scaffolding domain (CSD) peptide LTI-2355 modulates the phagocytic and synthetic activity of lung derived myeloid cells in Idiopathic Pulmonary Fibrosis (IPF) and Post-acute sequelae of COVID-fibrosis (PASC-F)

This study shows that the CSD peptide LTI-2355 improves phagocytic and reduces pro-inflammatory activity in myeloid cells from IPF and PASC-F patients.

Effects of anti-fibrotic standard of care drugs on senescent human lung fibroblasts

This study examines the effects of nintedanib and pirfenidone on senescent lung fibroblasts, finding they do not induce apoptosis and may increase fibrotic markers.

Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling following Respiratory Viral Infection.

This study shows that epithelial plasticity and innate immune activation contribute to lung tissue remodeling after viral infection, protecting against mortality but causing long-term lung dysfunction.

Single-Cell Transcriptomics Identifies Dysregulated Metabolic Programs of Aging Alveolar Progenitor Cells in Lung Fibrosis

This study identifies metabolic defects in alveolar progenitor cells during aging and lung injury that impair their renewal capacity.

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

Single cell reconstruction of human basal cell diversity in normal and IPF lung.

The paper uses single-cell RNA sequencing to analyze basal cell diversity in normal and IPF lung, finding increased secretory primed basal cells in IPF and roles for NOTCH2 and NOTCH3 in their regulation.

Targeting Lysyl oxidase-like 2 in Idiopathic Pulmonary Fibrosis

This study examines the role of LOXL2 in IPF using Simtuzumab, finding it enhances myofibroblast differentiation and fibrosis but shows no therapeutic efficacy.