CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation.
D. Hwang, L. L. W. Ishiwaka, A. Boehm, Z. Sahin, G. Casella, S. Jang, M. Seyedsadr, M. V. Gonzalez, J. P. Garifallou, H. Hakonarson, G.-X. Zhang, A. Rostami, B. Ciric
This study shows that blocking CSF-1 reduces harmful myeloid cells in EAE without affecting beneficial ones, suggesting CSF-1 as a therapeutic target for MS.
bioRxiv · Oct 23, 2020Immunology