G. Casella

In lupus nephritis, specific in situ inflammatory states are associated with refractory disease and progression to renal failure

Using deep machine learning to analyze confocal microscopy data, the study shows CD4-T cell populations in lupus nephritis organize into spatial neighborhoods predicting renal failure progression.

CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation.

This study shows that blocking CSF-1 reduces harmful myeloid cells in EAE without affecting beneficial ones, suggesting CSF-1 as a therapeutic target for MS.