LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread
Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard Liu Li, Cheryl E. G. Leyns, Lakshmi N. Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach B. Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M.‐Y. Lee, Danielle S. Bassett, Michael X. Henderson
This study shows that LRRK2 kinase inhibition reverses tau pathology progression in mice with the G2019S mutation but not in wildtype mice.
Translational Neurodegeneration · Mar 4, 2024Peer-reviewedNeuroscience