Author

Matthew J. Fell

Merck & Co., Inc., Rahway, NJ, USA (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Cheryl E. G. LeynsiD· 2 shared Michael X. HendersoniD· 2 shared Virginia M.‐Y. LeeiD· 2 shared Alice PrigentiD· 1 shared Alok K. Sharma· 1 shared Anastasia G. HenryiD· 1 shared Anthony A. EstradaiD· 1 shared Antonia Stepan· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Cheryl E. G. LeynsORCID

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Author profile →

3 papers

Recent·Most cited

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread

Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard Liu Li, Cheryl E. G. Leyns, Lakshmi N. Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach B. Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M.‐Y. Lee, Danielle S. Bassett, Michael X. Henderson

This study shows that LRRK2 kinase inhibition reverses tau pathology progression in mice with the G2019S mutation but not in wildtype mice.

Translational Neurodegeneration · Mar 4, 2024Peer-reviewedNeuroscience

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease

Cheryl E. G. Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan Galen Hatcher, Peining Tao, John J. Kang, EunRan R. Suh, Vivianna M. Van Deerlin, John Q. Trojanowski, Virginia M.‐Y. Lee, Matthew E Kennedy, Matthew J. Fell, Michael X. Henderson

The paper examines the relationship between glucocerebrosidase activity, lipid levels, and protein pathologies in Parkinson's disease and dementia with Lewy bodies.

npj Parkinson s Disease · May 11, 2023Peer-reviewedNeuroscience

LRRK2 kinase inhibitors induce a reversible effect in the lungs of non-human primates with no measurable pulmonary deficits

Marco A.S. Baptista, Kalpana Merchant, Ted Barrett, Diane K. Bryce, Michael Ellis, Anthony A. Estrada, Matthew J. Fell, Brian K. Fiske, Reina N. Fuji, Paul Galatsis, Anastasia G. Henry, Sue Hill, Warren Hirst, Christopher Houle, Matthew E. Kennedy, , Todd B. Sherer

This study evaluates the lung effects of LRRK2 kinase inhibitors in non-human primates, finding reversible histopathological changes without pulmonary function deficits.

bioRxiv · Aug 15, 2018 · PreprintPharmacology & Toxicology