Correcting mutant CFTR with a stabilizing nanobody reveals a novel active conformation of the channel
Marie Overtus, James N. Charlick, Tihomir Rubil, Andrew S. Paige, Blaine J. Loughlin, Zachary Rich, Mayuree Rodrat, Zhengrong Yang, Anita Balázs, John C. Kappes, Marcus Alexander Mall, David N. Sheppard, John Francis Hunt, Cédric Govaerts
This study uses a nanobody to stabilize mutant CFTR, revealing a novel active conformation and improving its function in cystic fibrosis.
bioRxiv · Oct 8, 2025 · PreprintBiochemistry