Author

James N. Charlick

University of BristolORCID 0000-0001-9798-7769Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Andrew S. PaigeiD· 1 shared Anita BalázsiD· 1 shared Blaine J. Loughlin· 1 shared Cédric GovaertsiD· 1 shared David N. SheppardiD· 1 shared John C. KappesiD· 1 shared John Francis HuntiD· 1 shared Marcus Alexander MalliD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrew S. PaigeORCID

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1 paper

Recent·Most cited

Correcting mutant CFTR with a stabilizing nanobody reveals a novel active conformation of the channel

Marie Overtus, James N. Charlick, Tihomir Rubil, Andrew S. Paige, Blaine J. Loughlin, Zachary Rich, Mayuree Rodrat, Zhengrong Yang, Anita Balázs, John C. Kappes, Marcus Alexander Mall, David N. Sheppard, John Francis Hunt, Cédric Govaerts

This study uses a nanobody to stabilize mutant CFTR, revealing a novel active conformation and improving its function in cystic fibrosis.

bioRxiv · Oct 8, 2025 · PreprintBiochemistry