A pre-rRNA positive feedback loop drives malignant ribosome biogenesis
Emilie L. Alard, Martin Dodel, Shannon N. Russell, Zeinab Rekad, Maximilian F. Wiesbeck, Maia Cooper, Zaynah Patel, Muhammad S. Azman, Maria R. Conte, Stefan H. Stricker, Keaton Ian Jones, Eric E. O’Neill, Faraz K. Mardakheh
This study identifies a pre-rRNA positive feedback loop driven by CK2 in the nucleolus that promotes malignant ribosome biogenesis and cancer growth.
bioRxiv · Jul 3, 2026 · PreprintCancer Biology