Stefan H. Stricker

Human cerebral assembloids as a model to study the interaction of glioblastoma with resident glial cells

This study develops human cerebral assembloids to model glioblastoma interactions with glial cells, revealing extracellular vesicles' role in peritumoral niche formation.

A pre-rRNA positive feedback loop drives malignant ribosome biogenesis

This study identifies a pre-rRNA positive feedback loop driven by CK2 in the nucleolus that promotes malignant ribosome biogenesis and cancer growth.

SLAM-seq reveals independent contributions of RNA processing and stability to gene expression in African trypanosomes

The paper uses SLAM-seq and scRNA-seq to show RNA processing and stability independently influence mRNA levels in African trypanosomes.

Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes

The paper identifies 61 novel mutations in the aged human testes, most affecting the RAS-MAPK pathway, showing evidence of selfish selection in the male germline.