Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesicles
Maria Kreger Karabova, Anna del Ser‐Badia, Anne Hedegaard, Sam J. Washer, Zeynep Baykam, Darragh Patrick O'Brien, Iolanda Vendrell, Svenja Hester, Roman Fischer, Errin Johnson, Charlotte E. Melia, Teige R. S. Matthews-Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A. Metrick, , Sally A. Cowley
This study shows human iPSC-derived microglia uptake and process tau fibrils, leading to secretion in extracellular vesicles that can seed tau aggregation in neurons.
Alzheimer s & Dementia · Apr 1, 2026Peer-reviewedCell Biology