Author

Zhengyang Chen

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Mingyue ZhengiD· 2 shared Ruirui YangiD· 2 shared Sulin ZhangiD· 2 shared Chen Zheng· 1 shared Chenmao Zhou· 1 shared Hao GuoiD· 1 shared Hualiang JiangiD· 1 shared Jiangshan Shi· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBioinformatics

Mingyue ZhengORCID

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2 papers

Recent·Most cited

Identify compound-protein interaction with knowledge graph embedding of perturbation transcriptomics

Shengkun Ni, Xiangtai Kong, Yingying Zhang, Zhengyang Chen, Zhaokun Wang, Zunyun Fu, Ruifeng Huo, Xiaochu Tong, Ning Qu, Xiaolong Wu, Kun Wang, Wei Dong Zhang, Runze Zhang, Zimei Zhang, Jiangshan Shi, , Mingyue Zheng

PertKGE improves compound-protein interaction prediction using knowledge graph embedding of perturbation transcriptomics, outperforming baselines in cold-start settings and identifying novel therapeutic targets.

bioRxiv · Apr 8, 2024 · PreprintBioinformatics

Drug design and repurposing with a sequence-to-drug paradigm

Lifan Chen, Zisheng Fan, Jie Chang, Ruirui Yang, Hao Guo, Yinghui Zhang, Tianbiao Yang, Chenmao Zhou, Zhengyang Chen, Chen Zheng, Xinyue Hao, Keke Zhang, Rongrong Cui, Yiluan Ding, Naixia Zhang, , Mingyue Zheng

This paper introduces a sequence-to-drug paradigm using TransformerCPI2.0 to discover drug-like molecules from protein sequences and validates its effectiveness for three targets.

bioRxiv · Mar 26, 2022 · PreprintMolecular Biology