Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate
Roberta Buono, Dennis Juarez, Madhuri Paul, Sarah J. Skuli, Ian B. Wong, Ishita Tarnekar, Zhili Ying, Izabelle Le, Gerald B. W. Wertheim, A’ishah Bakayoko, Marisa Kruidenier, Saı̈d M. Sebti, Marina Konopleva, Angela G. Fleischman, Cholsoon Jang, , David A. Fruman
This study shows pitavastatin overcomes venetoclax resistance in AML by depleting GGPP, inducing apoptosis through PUMA upregulation and MCL-1 reduction, and suppressing mitochondrial metabolism.
bioRxiv · Oct 27, 2025 · PreprintCancer Biology