Author

Ishita Tarnekar

University of California, IrvineORCID 0000-0002-0884-3550Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A’ishah Bakayoko· 1 shared Angela G. FleischmaniD· 1 shared Cholsoon JangiD· 1 shared David A. FrumaniD· 1 shared Dennis JuareziD· 1 shared Gerald B. W. WertheimiD· 1 shared Ian B. Wong· 1 shared Izabelle Le· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A’ishah Bakayoko

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1 paper

Recent·Most cited

Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate

Roberta Buono, Dennis Juarez, Madhuri Paul, Sarah J. Skuli, Ian B. Wong, Ishita Tarnekar, Zhili Ying, Izabelle Le, Gerald B. W. Wertheim, A’ishah Bakayoko, Marisa Kruidenier, Saı̈d M. Sebti, Marina Konopleva, Angela G. Fleischman, Cholsoon Jang, , David A. Fruman

This study shows pitavastatin overcomes venetoclax resistance in AML by depleting GGPP, inducing apoptosis through PUMA upregulation and MCL-1 reduction, and suppressing mitochondrial metabolism.

bioRxiv · Oct 27, 2025 · PreprintCancer Biology