A novel model demonstrating that human immune cells promote multiorgan SARS-CoV-2 dissemination and human T cells limit anti-viral innate immunity
Amber N. Wolabaugh, Vrushali V. Agashe, Zicheng Wang, Nichole M. Danzl, Christopher A. Parks, Mohsen Khosravi Maharlooei, Xiaolan Ding, Hao Wei Li, Candace D. Castagna, Giorgia Zanetti, Katherine D. Long, Yasmeen S. Saad, Anjali Saqi, Moriya Tsuji, Megan Sykes
This paper develops a human immune system mouse model to study SARS-CoV-2 dissemination and immune responses, finding that human T cells suppress innate immunity and allow viral persistence.
bioRxiv · Jun 19, 2026 · PreprintImmunology