Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth
Ying Zhang, Kaijing Chen, Seng Chuan Tang, Yichao Cai, Akiko Niibori-Nambu, Yi Xiang See, Chaoyu Fu, Anandhkumar Raju, Benjamin Lebeau, Zixun Ling, Jia Jia Chan, Yvonne Tay, Marek Mutwil, Manikandan Lakshmanan, Greg Tucker‐Kellogg, , Melissa J. Fullwood
The paper demonstrates that disrupting super-silencers via EZH2 and REST inhibition reduces chromatin interactions and cancer growth.
Nature Structural & Molecular Biology · Sep 20, 2024Peer-reviewedMolecular Biology