Discovery and Characterization of a Hydroxypyridone-3-carboxamide Analog as an Antiviral Lead against Orthopoxviruses
Anil Pant, Ajit Dhananjay Jagtap, Jiashu Xie, Djamal Brahim Belhaouari, Wei Xie, Jacob P. Mahoney, Lara Dsouza, Ziyue Wang, Zeinab R. Aboezz, Tibor Farkas, Zhengqiang Wang, Zhilong Yang
This study identifies ZW-2038, a hydroxypyridone-3-carboxamide analog, as an antiviral lead against orthopoxviruses with low micromolar potency and selectivity in human fibroblasts and organoid models.
Antimicrobial Agents and Chemotherapy · Jun 18, 2026Peer-reviewedMicrobiology