Uncompetitive Allosteric Inhibitor of Mitochondrial Creatine Kinase Prevents Binding and Release of Creatine by Stabilization of Loop Closure
Merve Demir, Chen-Ting Ma, Nikhil Puvvula, Laura Koepping, Palak Gosalia, Sirkku Pollari, Shaun Alba, Zoe Zong, Ya Li, Lynn Miya Fujimoto, Andrey A. Bobkov, Taro Hitosugi, Jianhua Zhao, Eduard A. Sergienko
The paper identifies an uncompetitive allosteric inhibitor of mitochondrial creatine kinase that stabilizes loop closure, preventing creatine binding and phosphocreatine release.
Journal of Molecular Biology · Jun 9, 2026Peer-reviewedBiochemistry