Author

Palak Gosalia

Sanford Burnham Prebys Medical Discovery Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

Alexander Aleshin· 1 shared Allison S. LimpertiD· 1 shared Andrey A. BobkoviD· 1 shared Carina D. Wimer· 1 shared Chen-Ting Ma· 1 shared David A. ScottiD· 1 shared Douglas J. SheffleriD· 1 shared Eduard A. SergienkoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

Alexander Aleshin

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2 papers

Recent·Most cited

Reversible, Orally Bioavailable Small-Molecule Inhibitors Occupy the Substrate Tunnel of the Thioesterase Domain of Fatty Acid Synthase

Joseph Fromm, Alexander Aleshin, Lester J. Lambert, Laurent J. S. De Backer, Santhi Reddy, Margrith E. Mattmann, Allison S. Limpert, Palak Gosalia, Carina D. Wimer, Fabiana Izidro Layng, Maria Celeridad, Robert Ardecky, Peter Teriete, David A. Scott, Michael P. Hedrick, , Nicholas D. P. Cosford

This paper reports the discovery of SBP-5917, a reversible FASN-TE inhibitor with submicromolar potency and cellular target engagement.

bioRxiv · Oct 7, 2026 · PreprintCell Biology

Uncompetitive Allosteric Inhibitor of Mitochondrial Creatine Kinase Prevents Binding and Release of Creatine by Stabilization of Loop Closure

Merve Demir, Chen-Ting Ma, Nikhil Puvvula, Laura Koepping, Palak Gosalia, Sirkku Pollari, Shaun Alba, Zoe Zong, Ya Li, Lynn Miya Fujimoto, Andrey A. Bobkov, Taro Hitosugi, Jianhua Zhao, Eduard A. Sergienko

The paper identifies an uncompetitive allosteric inhibitor of mitochondrial creatine kinase that stabilizes loop closure, preventing creatine binding and phosphocreatine release.

Journal of Molecular Biology · Jun 9, 2026Peer-reviewedBiochemistry