Author

Erich Koller

F. Hoffmann-La Roche AGORCID 0000-0001-9272-9576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Lars Joenson· 2 shared Annamaria Braendli-Baiocco· 1 shared Anne SpangiD· 1 shared Azad BonniiD· 1 shared Benjamin HaleyiD· 1 shared Carolina Hager· 1 shared Charlotte BoniD· 1 shared Christian WeileiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMolecular Biology

Lars Joenson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedOct 9, 2026

Antisense oligonucleotides targeting transcription termination windows disrupt mRNA 3' end processing and decrease gene expression

Kinga Winczura, Lars Joenson, Erich Koller…·Lukasz Jan Kielpinski

This study shows that antisense oligonucleotides targeting transcription termination windows can decrease gene expression by disrupting mRNA 3' end processing and causing off-target effects.

2 citationstop 5%

multiomeexperimental assay

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Cell BiologyNature CommunicationsPeer-reviewedJun 30, 2025

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular ASO activity

Liza Malong, Jessica Roskosch, Carolina Hager…·Filip Roudnicky

The paper uses a CRISPR/Cas9 screen to identify genes modulating ASO activity, revealing AP1M1 and TBC1D23 as key regulators of endosome-Golgi transport affecting ASO efficacy.

9 citations

humangenetic perturbation / CRISPR

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NeurosciencebioRxivPreprintJun 9, 2022

Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey

Ravi Jagasia, Charlotte Bon, Soren V. Rasmussen…·Marius Christian Hoener

The paper identifies a potent ASO targeting UBE3A-ATS in Angelman syndrome patient neurons, showing long-lasting effects in cynomolgus monkeys.

6 citations

humanmouse

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