The paper shows aging and Alzheimer's disease alter distinct functional connectivity axes in the brain, with AD affecting the sensory-association axis and aging affecting the representation-executive axis.

Nature Neuroscience · Oct 1, 2026Peer-reviewedNeuroscience

Patient-specific functional brain architecture explains cortical patterns of tau PET in Alzheimer's disease

Hamid Behjat, Jacob W. Vogel, Olof T. Strandberg, Nicola Spotorno, Nicolai Franzmeier, Léa Chauveau, Jonathan Ö. Rittmo, Sara Stampacchia, Lyduine Eisa Collij, Alexa Pichet Binette, Yu Xiao, Pavan Chaggar, Zeyu Zhu, the Alzheimer's Disease Neuroimaging Initiative, Dimitri Van De Ville, , Rik Ossenkoppele

The paper shows that individual functional brain connectivity improves the explanation of tau PET patterns in Alzheimer's disease compared to group-level data.

bioRxiv · Oct 2, 2025 · PreprintNeuroscience

Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer's Disease

Toomas Erik Anijärv, Rik Ossenkoppele, Ruben A Smith, Alexa Pichet Binette, Lyduine Eisa Collij, Hamid Behjat, Jonathan Ö. Rittmo, Linda Karlsson, Khazar Ahmadi, Olof T. Strandberg, the Alzheimer’s Disease Neuroimaging Initiative, Michael Walter Weiner, Paul S. S Aisen, Ronald Carl Petersen, Clifford R. Jack, , Oskar Hansson

The paper investigates whether hemispheric asymmetry in tau pathology in Alzheimer's disease is linked to reduced inter-hemispheric connectivity or asymmetric amyloid-beta distribution, finding a strong association with amyloid-beta laterality.

Nature Communications · Sep 5, 2025Peer-reviewedNeuroscience