Michael Walter Weiner

Comparing Harmonization Approaches for Protocol-Related Variability in Multisite Diffusion MRI Data

The paper compares three harmonization methods for multisite diffusion MRI data to reduce protocol-related variability while preserving associations with cognitive impairment and PET biomarkers.

Network-based amyloid-beta pathology predicts subsequent cognitive decline in cognitively normal older adults

This study uses machine learning to show that integrating brain connectome data with amyloid-beta PET imaging improves prediction of cognitive decline in older adults.

White Matter Tract Vulnerability to Amyloid Pathology on the Alzheimer's Disease Continuum

This study uses BUAN tractometry to assess how amyloid positivity affects white matter tracts in Alzheimer's disease, revealing localized microstructural changes associated with amyloid pathology.

DTI versus NODDI White Matter Microstructural Biomarkers of Alzheimer's Disease

The paper compares DTI and NODDI models using dMRI data from ADNI participants to assess their ability to detect AD-related biomarkers like cognitive impairment and amyloid-beta/tau pathology.

Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer's Disease

The paper investigates whether hemispheric asymmetry in tau pathology in Alzheimer's disease is linked to reduced inter-hemispheric connectivity or asymmetric amyloid-beta distribution, finding a strong association with amyloid-beta laterality.

Microstructural Mapping of Neural Pathways in Alzheimer's Disease using Macrostructure-Informed Normative Tractometry

This study introduces MINT, a framework that jointly models white matter microstructure and macrostructure to better detect anomalies in MCI and dementia, showing improved sensitivity compared to traditional diffusion metrics.

Polygenic effects on the risk of Alzheimer's disease in the Japanese population

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2

This study identifies two novel Alzheimer's disease-associated genes, DTNB and DLG2, by analyzing rare variants in whole-genome sequencing data from AD family datasets.

Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

This study uses an epidemic spreading model to show that tau spreads through neuronal connections in Alzheimer's disease, with beta-amyloid accelerating this process in some brain regions.

The Alzheimer’s Disease Metabolome: Effects of Sex and APOE ε4 genotype

The paper investigates sex and APOE ε4 genotype effects on metabolic alterations in Alzheimer’s disease using stratified analysis of serum metabolites.

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

This study compares whole hippocampus and subfield biomarkers for Alzheimer’s disease detection and prediction using multimodal MRI data, finding subiculum biomarkers improve prediction accuracy.

Serum triglycerides in Alzheimer’s disease: Relation to neuroimaging and CSF biomarkers

The paper investigates the association between triglyceride principal component scores and Alzheimer's disease biomarkers in the ADNI cohort, finding significant links with MCI, AD, and specific brain structures.

A blood-based signature of cerebral spinal fluid Aβ1-42 status

This paper develops a blood-based machine learning model to predict cerebral spinal fluid Aβ1-42 levels, showing high accuracy in identifying Alzheimer's disease risk.

Diffusion MRI Indices and their Relation to Cognitive Impairment in Brain Aging: The updated multi-protocol approach in ADNI3

The paper analyzes diffusion MRI data from ADNI3 to assess how different protocols affect diffusion indices and their association with cognitive impairment and age.

Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut Microbiome

The paper identifies altered bile acid profiles in Alzheimer's disease, linking them to cognitive impairment and genetic variants through a large study.

Altered Bile Acid Profile in Mild Cognitive Impairment and Alzheimer’s Disease: Relationship to Neuroimaging and CSF Biomarkers

The paper identifies associations between serum bile acid metabolites and AD biomarkers in the A/T/N framework, suggesting a potential role for bile acid pathways in AD pathophysiology.

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

This paper introduces SuStaIn, a machine learning method that identifies disease subtypes and their temporal progression from cross-sectional data, improving prediction of diagnostic conversion in neurodegenerative diseases.

Heritability of regional brain volumes in large-scale neuroimaging and genetic studies

The paper examines the heritability of regional brain volumes using genetic and neuroimaging data from multiple cohorts, finding high heritability and consistent patterns across populations.

Do Candidate Genes Affect the Brain’s White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

The paper evaluates 15 candidate SNPs associated with psychiatric disorders using 6,165 diffusion MRI scans, finding no significant associations after correction for multiple testing.