Wiebke Arlt

The paper develops and validates a UHPLC-MS/MS assay for quantifying 18 steroids in serum, showing improved sensitivity and applied it to healthy individuals.

Inhibition of AKR1C3 reduces 11-oxygenated androgens but not classic androgens in women.

This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.

The paper develops a mouse model of aldosterone-producing adenoma to test thermal ablation therapies, showing reduced aldosterone production after treatment.

The paper shows that male sex hormones and reduced plakoglobin impair atrial conduction and sodium currents in mice, contributing to atrial remodelling.

The paper demonstrates an alternative androgen biosynthesis pathway in human fetal females with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency, leading to virilization despite low circulating androgens.