Author

Jonathan Sulc

École Polytechnique Fédérale de LausanneORCID 0000-0002-5572-6541Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Approach:benchmark study· 1 Organism:C. elegans· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jean‐David MoreliD· 2 shared Johan H. AuwerxiD· 2 shared Maroun S. Bou SleimaniD· 2 shared Xiaoxu LiiD· 2 shared Alessia PerinoiD· 1 shared Alexis BachmanniD· 1 shared Alexis RapiniD· 1 shared Amélia LalouiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersSystems Biology

Jean‐David MorelORCID

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3 papers

Recent·Most cited

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Arwen W. Gao, Gaby El Alam, Yunyun Zhu, Weisha Li, Jonathan Sulc, Xiaoxu Li, Elena Katsyuba, Terytty Yang Li, Katherine A. Overmyer, Amélia Lalou, Laurent Mouchiroud, Maroun S. Bou Sleiman, Matteo Cornaglia, Jean‐David Morel, Riekelt H. Houtkooper, , Johan H. Auwerx

The paper identifies genetic and molecular regulators of lifespan in C. elegans using a recombinant inbred population and validates their relevance to human age-related diseases.

Cell Reports · Oct 1, 2024Peer-reviewedSystems Biology

Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population

Xiaoxu Li, Jean‐David Morel, Giorgia Benegiamo, Johanne Poisson, Alexis Bachmann, Alexis Rapin, Jonathan Sulc, Evan G. Williams, Alessia Perino, Kristina Schoonjans, Maroun S. Bou Sleiman, Johan H. Auwerx

The paper identifies genetic and dietary factors influencing intestinal inflammation in BXD mice, finding MUC4 and EPHA6 as potential mediators of IBD susceptibility.

bioRxiv · Mar 22, 2023 · PreprintSystems Biology

Polynomial Mendelian Randomization reveals widespread non-linear causal effects in the UK Biobank

Jonathan Sulc, Jennifer Sjaarda, Zoltán Kutalik

This paper introduces PolyMR, a polynomial MR method that reveals non-linear causal effects in UK Biobank data, finding 84% of tested effects deviate from linearity.

bioRxiv · Dec 8, 2021 · PreprintGenetics