Evan G. Williams

Voluntary Exercise Differentially Affects High-Fat Induced Metabolic Phenotypes Across BXD Mouse Strains

The paper shows that voluntary exercise improves glucose tolerance in some BXD mouse strains on a high-fat diet, independent of caloric intake, and suggests gut microbiota may mediate this effect.

Complex Assembly and Activity States as Multifaceted Protein Attributes Explaining Phenotypic Variability

The paper introduces a multi-omics framework to analyze protein activity in context-specific networks, demonstrating its utility in linking molecular profiles to phenotypic outcomes using HeLa and Kyoto cell lines.

Integrative Analysis of the Mouse Cecal Microbiome Across Diet, Age, and Weight in the Diverse BXD Population

This study integrates microbiome and host transcriptome data from mice to show diet, age, and genetics influence gut microbiota, with machine learning models predicting body weight and age with high accuracy.

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

The Pgb1 locus controls glycogen aggregation in astrocytes of the aged hippocampus without impacting cognitive function

The paper identifies the Pgb1 locus as controlling glycogen aggregation in aged hippocampal astrocytes without affecting cognitive function.

A multiomic network approach uncovers disease modifying mechanisms of inborn errors of metabolism

The paper identifies modifier pathways for inborn errors of metabolism using multiomic data and gene regulatory networks from healthy populations.

Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population

The paper identifies genetic and dietary factors influencing intestinal inflammation in BXD mice, finding MUC4 and EPHA6 as potential mediators of IBD susceptibility.

Multi-Omic Profiling of the Liver Across Diets and Age in a Diverse Mouse Population

The paper uses multi-omics data from mice to identify gene-environment-age interactions and causal molecular networks linked to longevity.

Gene-by-environmental modulation of longevity and weight gain in the murine BXD family

The paper examines how diet and genetics interact to affect longevity and weight gain in mice, finding that genetic differences significantly influence the impact of high-fat diets on lifespan.

Towards a systematic characterization of protein complex function: a natural language processing and machine-learning framework

PCfun annotates protein complex function using natural language processing and machine learning, integrating word embeddings from PubMed Central articles with supervised and unsupervised methods.

SECAT: Quantifying differential protein-protein interaction states by network-centric analysis

SECAT quantifies differential protein-protein interaction states across cellular states by analyzing PPI networks, showing improved scalability and effectiveness over previous methods.

Body weight at young adulthood and association with epigenetic aging and lifespan in the BXD murine family

This study examines the relationship between body weight, epigenetic aging, and lifespan in BXD mouse strains, finding that higher body weight and high-fat diet accelerate epigenetic aging and shorten lifespan.

The expanded BXD family of mice: A cohort for experimental systems genetics and precision medicine

BXD mouse family doubled to 150 inbred strains segregating over 6 million variants, with roughly 10,000 located recombinations and a public phenome exceeding 7000 traits.

Genomic, Proteomic and Phenotypic Heterogeneity in HeLa Cells across Laboratories: Implications for Reproducibility of Research Results

This study quantifies genomic, proteomic, and phenotypic variability in HeLa cells across laboratories and passages, revealing implications for research reproducibility.