Kailash Venkatraman

This study shows that saturated cardiolipins (CLsat) disrupt inner mitochondrial membrane structure and function, contributing to mitochondrial dysfunction in Barth syndrome.

The paper uses molecular dynamics simulations to show cardiolipin increases membrane spontaneous curvature and reduces bending rigidity, leading to lateral heterogeneities through curvature sensing.

This study shows that cardiolipin remodeling is essential for maintaining inner mitochondrial membrane structure in yeast under low oxygen conditions and identifies Ddl1p as a regulator of CL levels.