Author

Zachary L. Robbe

University of North Carolina at Chapel HillORCID 0000-0001-5154-0742Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genomics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Frank L. ConloniD· 2 shared Ileana M. CristeaiD· 2 shared Wei ShiiD· 2 shared Xinlei ShengiD· 2 shared Abraham L. BayeriD· 1 shared Arthur P. ArnoldiD· 1 shared Austin J. HepperlaiD· 1 shared Brynn N. AkerbergiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersGenomics

Frank L. ConlonORCID

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3 papers

Recent·Most cited

PathologyCirculation ResearchPeer-reviewedOct 28, 2026

T cell-derived IFNγ instructs ECM crosslinking by cardiac fibroblasts through LOXL3 in experimental cardiometabolic HFpEF

Ramona Emig, Zachary L. Robbe, Celina Kley…·Pilar Alcaide

This study identifies T cell-derived IFNγ as a driver of ECM stiffening in HFpEF via LOXL3 in cardiac fibroblasts, showing therapeutic potential for targeting this pathway.

2 citationstop 2%

mouseexperimental assay

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GenomicsbioRxivPreprintOct 28, 2021

CHD4 is recruited by GATA4 and NKX2-5 silencers to repress non-cardiac gene programs in the developing heart

Zachary L. Robbe, Wei Shi, Lauren K. Wasson…·Frank L. Conlon

The paper identifies how CHD4/NuRD is recruited to cardiac gene loci via interactions with GATA4, NKX2-5, and TBX5, revealing its role in repressing non-cardiac gene programs during heart development.

DOI 10.1101/2021.10.28.466285

mouseDNA methylation

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Developmental BiologybioRxivPreprintSep 29, 2020

Cardiac Sex Differences are Established Prior to Gonad Formation

Wei Shi, Xinlei Sheng, Kerry M. Dorr…·Frank L. Conlon

The paper identifies sex-specific transcriptomes and proteomes in cardiac tissue, showing that sex differences are established before gonad formation through post-transcriptional mechanisms and hormonal/sex chromosomal factors.

3 citations

mouseproteomics

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