Author

Xinlei Sheng

Princeton UniversityORCID 0000-0002-5067-8915Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Xinlei Sheng2 papers · Shenzhen Medical Academy of Research and Translation

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Frank L. ConloniD· 2 shared Ileana M. CristeaiD· 2 shared Wei ShiiD· 2 shared Zachary L. RobbeiD· 2 shared Adelina AndreiiD· 1 shared Arthur P. ArnoldiD· 1 shared Austin J. HepperlaiD· 1 shared Benjamin Aaron GarciaiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersGenomics

Frank L. ConlonORCID

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3 papers

Recent·Most cited

A circular engineered sortase for interrogating histone H3 in chromatin

Samuel D. Whedon, Kwangwoon Lee, Zhipeng A. Wang, Emily Zahn, Congcong Lu, Maheeshi Yapa Abeywardana, Louise Fairall, Eunju Nam, Sarah E. DuBois-Coyne, Pablo De Ioannes, Xinlei Sheng, Adelina Andrei, Emily Lundberg, Jennifer Jiang, Karim‐Jean Armache, , Philip A. Cole

This paper introduces an engineered sortase, cW11, for modifying and isolating histone H3 tails to study epigenetic modifications and their effects on enzyme processing and protein recognition.

Journal of the American Chemical Society · Nov 25, 2024Peer-reviewedBiochemistry

CHD4 is recruited by GATA4 and NKX2-5 silencers to repress non-cardiac gene programs in the developing heart

Zachary L. Robbe, Wei Shi, Lauren K. Wasson, Caralynn M. Wilczewski, Xinlei Sheng, Austin J. Hepperla, Brynn N. Akerberg, William T. Pu, Ileana M. Cristea, Ian J. Davis, Frank L. Conlon

The paper identifies how CHD4/NuRD is recruited to cardiac gene loci via interactions with GATA4, NKX2-5, and TBX5, revealing its role in repressing non-cardiac gene programs during heart development.

bioRxiv · Oct 28, 2021 · PreprintGenomics

Cardiac Sex Differences are Established Prior to Gonad Formation

Wei Shi, Xinlei Sheng, Kerry M. Dorr, Josiah E. Hutton, Haley A. Davies, Tia D. Andrade, Todd M. Greco, Yutaka Hashimoto, Joel D. Federspiel, Zachary L. Robbe, Xuqi Chen, Arthur P. Arnold, Ileana M. Cristea, Frank L. Conlon

The paper identifies sex-specific transcriptomes and proteomes in cardiac tissue, showing that sex differences are established before gonad formation through post-transcriptional mechanisms and hormonal/sex chromosomal factors.

bioRxiv · Sep 29, 2020 · PreprintDevelopmental Biology