Ileana M. Cristea

A Temporal Interactome Atlas across RNA Viruses reveals Convergent Vulnerabilities for Antiviral Repurposing

The paper builds an InterVir Atlas to map temporal interactome changes across RNA viruses and identifies convergent host vulnerabilities for antiviral drug repurposing.

Targeted quantification assays for DNA repair and handling proteins and interactions in Huntington's disease models

The paper develops targeted mass spectrometry assays to quantify DNA repair and handling proteins in Huntington's disease models and finds HTT influences their abundance and interactions.

Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntingtons disease

The paper uses RNAi to identify dose-dependent MMR gene modulators of somatic instability and proteome changes in HD mouse models.

Ribosome Molecular Aging Shapes Translation Dynamics

The paper shows that molecularly aged ribosomes alter translational dynamics by impairing elongation and increasing ribosome collisions during organismal aging.

The Kaposi's sarcoma-associated herpesvirus viral genome packaging accessory factor ORF68 forms cytoplasmic puncta dependent on the viral tyrosine kinase

This study identifies a novel cytoplasmic function of the KSHV packaging factor ORF68, dependent on its interaction with the viral tyrosine kinase ORF21.

Lineage memory shapes viral resistance barriers in human skin

The paper shows that viral resistance in human skin cells is inherited through cellular lineages and preserved across generations.

Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures

The paper identifies striatum-selective molecular interactions of huntingtin using multi-epitope assays and models, revealing its role in transcriptional regulation and disease mechanisms.

ARPE-19 Epithelial Cells Fail To Initiate Type-I Interferon Signaling in Response to Human Cytomegalovirus Infection.

This study shows that ARPE-19 cells fail to initiate type-I interferon signaling in response to HCMV infection due to low expression of key pattern recognition receptors and signaling molecules.

The viral packaging motor potentiates late gene expression in Kaposi's sarcoma-associated herpesvirus

The paper identifies ORF29 as a viral DNA packaging motor subunit that potentiates late gene expression in KSHV, linking transcription and packaging processes.

Quantitative Proteomic Profiling of Murine Embryonic Heart Development Reveals a Role for the Mevalonate Pathway in Cardiomyocyte Proliferation

The paper uses quantitative proteomics to study murine embryonic heart development and identifies the mevalonate pathway's role in cardiomyocyte proliferation.

CHD4 is recruited by GATA4 and NKX2-5 silencers to repress non-cardiac gene programs in the developing heart

The paper identifies how CHD4/NuRD is recruited to cardiac gene loci via interactions with GATA4, NKX2-5, and TBX5, revealing its role in repressing non-cardiac gene programs during heart development.

The axonal sorting activity of pseudorabies virus Us9 protein depends on the state of neuronal maturation

This study shows that the Us9 protein of pseudorabies virus regulates axonal sorting differently in immature versus mature neurons, with immature neurons showing reduced Us9-dependent sorting and increased Us9-independent transport.

Cardiac Sex Differences are Established Prior to Gonad Formation

The paper identifies sex-specific transcriptomes and proteomes in cardiac tissue, showing that sex differences are established before gonad formation through post-transcriptional mechanisms and hormonal/sex chromosomal factors.

Consensus clustering of herpesvirus protein interaction networks provides insights into their evolutionary relationship with bacteriophages

This study uses consensus clustering of HSV1 protein interaction networks to uncover evolutionary links between herpesviruses and bacteriophages, identifying pUS10 as a potential evolutionary vestige.

Changes in mRNA abundance drive differential shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

The paper shows that changes in mRNA decay alter RNA binding protein localization, linking cytoplasmic RNA degradation to transcription.