Cardiac Sex Differences are Established Prior to Gonad Formation
Wei Shi, Xinlei Sheng, Kerry M. Dorr, Josiah E. Hutton, Haley A. Davies, Tia D. Andrade, Todd M. Greco, Yutaka Hashimoto, Joel D. Federspiel, Zachary L. Robbe, Xuqi Chen, Arthur P. Arnold, Ileana M. Cristea, Frank L. Conlon
The paper identifies sex-specific transcriptomes and proteomes in cardiac tissue, showing that sex differences are established before gonad formation through post-transcriptional mechanisms and hormonal/sex chromosomal factors.
bioRxiv · Sep 29, 2020 · PreprintDevelopmental Biology