Philipp G. Maass

The paper identifies a distributed architectural code involving cytoskeletal, membrane, and lipid regulators that governs nuclear reshaping during DNA repair.

The paper uses O-MAP to study a cardiac-specific RNA factory around TTN RNA, revealing its chromatin interactions, RNA composition, and role of RBM20 in gene regulation.

The paper shows that DNA double-strand breaks are repaired by nuclear envelope tubules formed through cytoplasmic microtubule interactions, enhancing repair accuracy and cancer therapy efficacy.

This study shows environmental enrichment alters chromatin structure, transcription factor binding, and 3D genome organization in mice, affecting cognitive function and gene regulation.

The paper uses CRISPR interference to identify lncRNA loci critical for differentiation and pluripotency in human embryonic stem cells.

The paper measures cis and trans effects on regulatory elements between human and mouse to show cis-trans compensation is uncommon within individual elements.

The paper uses computational methods and MPRA to analyze lncRNA and mRNA promoters, finding that divergent promoters have higher transcriptional activity and lower tissue-specificity, while lincRNAs and eRNAs are more tissue-specific with simpler TF motif profiles.

The paper identifies RNA sequences responsible for nuclear enrichment in lncRNAs using a modified MPRA approach and validates findings with smRNA-FISH.