Timothy L. Frankel

The paper analyzes spatial organization of immune and epithelial cells in colorectal and pancreatic cancers using multiplexed imaging, finding differences in conditional coordination and proximity between disease subtypes.

The paper analyzes matched pre- and post-chemotherapy biospecimens in pancreatic cancer, revealing that cancer-associated fibroblasts undergo neural reprogramming, characterized by axonal guidance gene enrichment, which may contribute to chemoresistance and tumor progression.

This study isolates and characterizes microbiota from human pancreatic tumors and small intestine, revealing how a Klebsiella oxytoca strain affects the tumor microenvironment and therapy response.

This study shows that ferroptosis in pancreatic cancer cells induces both pro- and anti-inflammatory signals, creating an immunosuppressive tumor microenvironment in mouse models.

The paper identifies a KRT17-positive, low-grade epithelial population in IPMNs with malignant features using spatial transcriptomics and single-cell RNA sequencing.

This study investigates the role of aspartate transaminases in pancreatic development and cancer progression using conditional knockout mice, finding that their loss does not affect tumor growth but impacts pancreas size in double knockout models.

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

This study shows EGFR activation in cholangiocytes drives extrahepatic bile duct regeneration after injury by promoting proliferation and altering ligand-receptor dynamics.

This study develops an immunocompetent mouse model of liposarcoma that recapitulates human tumor subtypes and immune features, enabling preclinical immunotherapy research.

The paper identifies a transcriptional transition state in ccRCC cells that drives sarcomatoid transformation and enhances immunotherapy response via macrophage and T-cell interactions.

This paper uses spatial transcriptomics to identify low-risk and high-risk expression programs in IPMN that correlate with exocrine and basal-like PDAC signatures, improving risk stratification.

This study identifies SLC4A11 as a mediator of ammonia import in hepatocellular carcinoma, showing its role in promoting cancer stemness and tumor growth.